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While a terrorist epidemy strikes the world leaders, the commissaire San-Antonio and his partner, the lieutenant Bérurier, have to escort the French ambassador in a British hotel. But after a negligence of Bérurier (one more little sex affair...), San-Antonio witnessed, helpless, to the ambassador's abduction, organized by a gorgeous Italian girl. Back to Paris, San-Antonio is dismissed by the police chief, Achille Hachille. A real godsend for Bérurier, who get promoted... But soon, the situation degenerates, when the president of the Republic mysteriously disappears. Immediate reaction from Police Minister : San-Antonio is the only one who can save the day. He has 48 hours and a secret squad to find the president. At the Elysée, San-Antonio finds Bérurier, the official investigator. But now, it's every man for himself : who will be the first to find the President ?